منابع مشابه
Confined compression of collagen hydrogels.
Reconstituted collagen hydrogels are often used for in vitro studies of cell-matrix interaction and as scaffolds for tissue engineering. Understanding the mechanical and transport behaviours of collagen hydrogels is therefore extremely important, albeit difficult due to their very high water content (typically >99.5%). In the present study the mechanical behaviour of collagen hydrogels in confi...
متن کاملModified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes.
Tissue engineering of clinically applicable dermo-epidermal skin substitutes is crucially dependent on the three-dimensional extracellular matrix, supporting the biological function of epidermal and dermal cells. This matrix essentially determines the mechanical stability of these substitutes to allow for safe and convenient surgical handling. Collagen type I hydrogels yield excellent biologica...
متن کاملFibroblast Phenotype within Concentrated Collagen Hydrogels
Introduction Normal collagen hydrogels (NCH), developed by Bell and co-workers, associated with sheets of keratinocytes are already used as skin temporary coverage (Apligraf ®). Nevertheless, NCH have several drawbacks such as extensive collagen hydrogel contraction, inhibition of cell growth and poor mechanical properties. In addition, cell death by apoptosis is observed. Because of their char...
متن کاملUniversal behavior of hydrogels confined to narrow capillaries
Flow of soft matter objects through one-dimensional environments is important in industrial, biological and biomedical systems. Establishing the underlying principles of the behavior of soft matter in confinement can shed light on its performance in many man-made and biological systems. Here, we report an experimental and theoretical study of translocation of micrometer-size hydrogels (microgel...
متن کاملEvaluating the effect of pH on mechanical strength and cell compatibility of nanostructured collagen hydrogel by the plastic compression method
Objective(s): One of the main constraints of collagen hydrogel scaffolds for using in tissue engineering is mechanical weakness. Plastic compression (PC) is a physical method to overcome the mechanical limitation of collagen hydrogel. Materials and Methods: In this study, the effects of pH on mechanical and biological properties of PC hydrogels were investigated. Collagen hydrogels were fabrica...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2013
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2012.11.048